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New small-molecule approaches that selectively inhibit both TNF- and IL-1 activities could provide greater clinical activity

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Collectively, these findings underscore the influence of amino acid metabolism on B-cell functionality, with potential implications for the inflammatory response and the pathogenesis of CHD

Upregulation or modulation of genes involved in the ergosterol biosynthetic pathway (ERG family), as well as modifications to sterol content, may alter the binding or activity of polyenes, and in the case of azoles, change the abundance of the target enzyme (lanosterol 14-demethylase), which affects its activity

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