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The content is solely the responsibility of the authors and does not necessarily represent the official views of the RSNA R&E Foundation

Br J Dermatol 173(6):13871399

Specifically, Toll-like receptor (TLR) engagement by pathogen-associated molecular patterns (PAMPs) activates RIPK3 via the adapter proteins TRIF or ZBP1, thereby bypassing RIPK1 to directly promote MLKL phosphorylation and execute the necroptotic death program