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Statistical analysis was done using Prism 7.0 (Graphpad software)

TIGAR inhibits excessive autophagy and the degradation of tight junction proteins by promoting the flux of pentose phosphate pathway (PPP) and the production of nicotinamide adenine dinucleotide phosphate (NADPH), and then protects the structural integrity of tight junctions in cerebral microvascular endothelial cells (Wang et al., 2017a)

Within the same study, scRNA-seq revealed 49 upregulated and 211 downregulated genes in CALHM2 -KO cells

In line with previous observations in CLL cell lines, CB-839 did not cause significant apoptosis in the cells, and the level of double-negative events as determined using annexin V/PI staining remained stable in all the treatment groups (P = 0.93)

Molecular Psychiatry

consistent with this, truncated Syn shows stronger membrane binding than Syn WT 49