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high-fat diet feeding diminished fatty acid -oxidation, as indicated by remarkably decreased hepatic mRNA levels of Carnitine palmitoyltransferase 1 A ( Cpt1a ) , Solute carrier family 25 member 20 ( Slc25a20 ) , Acyl-CoA dehydrogenase, medium-chain (Acadm), Acyl-CoA dehydrogenase, short-chain (Acads) , and Peroxisome proliferator-activated receptor alpha ( Ppara ) in MASLD mice (Fig

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On the other hand, mTOR also participates in mitochondrial quality control and coordinates the degradation of defective organelles via autophagy and mitophagy

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