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Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis

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Filling the type 1 site may also affect PEDF binding to type I collagen as it would reduce the negative surface charge of Asp300, a key residue crucial for collagen recognition 86 that is adjacent to the Zn 2+ -coordinating His299 (Fig

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This heterogeneity hinders replication of therapeutic outcomes and introduces uncertainty in efficacy and safety assessment

Eigler A, Matschke V, Hartmann G, Erhardt S, Boyle D, Firestein GS, Endres S: Suppression of TNF-alpha production in human mononuclear cells by an adenosine kinase inhibitor