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Nat Commun (2016) 7:12499

Age-related disturbances in glutathione reductase activity have been also reported (59), and an increasing frequency of glutathione transferase GSTT1 homozygous deletions is also associated with age (7, 22, 68-70)

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Mechanically, researchers have demonstrated that in TC, the absence of MIEAP expression, which indicates impaired MIEAP-mediated noncanonical mitophagy, leads to the accumulation of dysfunctional mitochondria [172]

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Mazer and Perrone, 2008)