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10.1007/s13167-021-00263-0 2

An increase in levels of total bile acid, especially primary bile acids and ursodeoxycholic acid (UDCA), and propionate levels was seen in stool samples of subjects with worsening fibrosis

2022 Feb 9;96(3):e0110321

S.NasirK.et al (2021)

If you don't, expect your development timeline to double

The first is the antioxidant barrier: polyphenols establish antioxidant defense by activating the Nrf2 signaling pathway, and Nrf2 upregulates the expression of HO-1, SOD-1, NQO-1 and other oxidative genes, so as to increase the number of antioxidant enzymes (SOD/CAT/GPX/GSH), and to neutralize cisplatin-induced reactive oxygen species (ROS) and reactive nitrogen species (RNS)