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If a supplement is taken daily, at gram doses, for months, it deserves the same tracking you would give training load: dose, duration, benefits, side effects, and a clear stop rule

10.1016/S0092-8674(00)80493-6

Recent experiments showed a surge in IL-6, IL-1, and TNF- levels within irradiated mice serum, which is revoked in MyD88-deficient animals

Efflux transporters expressed at the BBB limit the brain access of such drugs, which are substrates of these transporters

Aoyama M, Kawase H, Bando YK, Monji A, Murohara T (2016) Dipeptidyl peptidase 4 inhibition alleviates shortage of circulating glucagon-like peptide-1 in heart failure and mitigates myocardial remodeling and apoptosis via the exchange protein directly activated by cyclic AMP 1/Ras-related protein 1 axis