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Overproduction of Haptocorrin Finally, some cases show the over production of other molecules which also bond to vitamin B12, most commonly the so-called haptocorrin or R-binder, to which transcobalamin I and III belong

and both remain research-use-only outside trials

Together with the observation that CNS myelin appears to be a major target, this spurred development of various animal models, with the experimental autoimmune encephalomyelitis (EAE) mouse model being the most popular (Baxter, 2007)

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