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In an ideal world, preclinical and clinical studies would always use the same techniques (e.g., the same anticoagulant for sample collection, process samples from one individual at a time, control for environmental confounds, etc.)

In contrast, shoot-based mechanisms primarily involve intracellular Fe compartmentalisation and enzymatic detoxification through superoxide dismutase (SOD) and ascorbate peroxidase (APX) 24,25,96

This work was supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases Grants [R01 DK 070195], [R01 DK102142], and [R01 DK125465], the National Institute of General Medicine Grants [P20 GM103549] and [P30 GM118247]

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