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As in the case of PCOS, elevated testosterone in both males and females is associated with increased oil production in the skin, resulting in acne

In cancer patients with weight loss, megestrol acetate has been reported to have beneficial effects on appetite and results in a slight increase in weight, but it has not produced improvements in lean body mass or quality of life.[31] Further, serious complications of its use have been reported, including increased risk for thromboembolism, adrenal insufficiency, and hypogonadism in male patients.[32] A Cochrane review of 35 trials in 2013 reported that megestrol acetate did improve appetite and was associated with a slight gain in weight, but the authors emphasized that patients should be informed about the risks prior to taking megestrol.[31] Dronabinol, a constituent of cannabis, has been studied for appetite stimulation in cancer patients

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EXPIRATION DATE The drug retains its quality and effect for 3 years from the date of production, which is indicated on the package