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doi: 10.1111/j.1749-6632.1990.tb00140.x 44 TaylorEW

Glaucomatous optic neuropathy: mitochondrial dynamics, dysfunction and protection in retinal ganglion cells

Abe C, Miyazawa T, Miyazawa T

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H 2 O 2 reacts with ferrous iron (Fe 2+ ) in the Fenton reaction generating the highly toxic hydroxyl radical (OH) which can damage all cellular macromolecules (Imlay, 2003, 2008)

High GSH content within astrocytes protects them from oxidative stress and preserves their ability for glutamate uptake, ion homeostasis, and immune signaling (Takahashi and Mashima, 2022)