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Estudios en modelos animales sugieren efectos ansiolticos y antidepresivos, posiblemente mediados por la interaccin con los sistemas dopaminrgico y serotoninrgico

Stress-inflammatory/oxidative pathway activation results in increased transforming growth factor- (TGF-) signaling, which activates SMAD3 and increased NADPH Oxidase 2(NOX2) expression and activity at the RyR2 channel, leading to oxidation and calstabin 2 depletion from the channel macromolecular complex

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doi: 10.3389/fimmu.2025.1709354 Received 20 September 2025 Revised 05 November 2025 Accepted 10 November 2025 Published 28 November 2025 Volume 16 - 2025 Edited by Uzma Saqib, Devi Ahilya University, India Reviewed by Dongcheng Liu, Jinan University, China Yao Tong, University of California, San Francisco, United States Updates Copyright 2025 Wei, Lin, Li, Liu, Yang, Chen, Han, Wang, Qian, Ju and Zheng