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Beyond these receptors, there is another binding site that was initially considered to be another membrane-bound receptor (MT3) but was ultimately found to be the enzyme quinone reductase 2 (QR2) (Nosjean et al

doi: 10.3389/fmars.2021.725899 177 MaQ.LiL

doi: 10.1186/1744-9081-9-19 100

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Practical non-invasive methods include retrospective calculation of the iron removed based on the number and volume of therapeutic phlebotomies undertaken to reduce the serum ferritin level to 50100 g/L, based on a 500 mL phlebotomy removing approximately 250 mg of iron [51, 94], as well as magnetic resonance imaging

2d) in the presence of SAM suggests potential crosstalk communication between regulatory domains from neighbouring CBS proteins (inter-dimer) in the filament (Supplementary Movie 1)