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Bound GH is cleared more slowly and has a biological t 1/2 ~10 times that of unbound GH, suggesting that the bound hormone may provide a GH reservoir that dampens acute fluctuations in GH levels associated with its pulsatile secretion

Guidance from experts is therefore crucial

doi:10.1507/endocrj.52.571

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Data selection and screening This systematic review was conducted in accordance with the PRISMA 2020 guidelines, and the PRISMA checklist was followed throughout the process

While human clinical trials remain limited, the depth of animal research, consistency of positive findings across multiple study designs, and extensive community experience create a reasonable basis for therapeutic use