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As with any therapy, long-term studies are still limited, so ongoing observation and clinical research will further define its safety profile

While additional studies are needed to determine whether elevated vitamin B 12 status may be related to cancer development, including evaluating whether it might be a potential marker of cancer, it is important for observational studies to adequately control for potential confounders, such as age, menopausal status, alcohol use, and intake of the B-vitamin folate

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Transcriptome and metabolome reprogramming in Vitis vinifera cv