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Studies continue to accumulate evidence that correlate microbiome alterations with depression, promising microbiota-based approaches pending further validation

Furthermore, in other disease models (such as A-induced nerve cell damage), highly expressed or activated VDAC1 has been clearly involved in ferroptosis, exacerbating cell death by inhibiting anti-ferroptosis pathways (such as GPX4, AMPK/mTOR, Wnt/-catenin) (149)

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10.1016/j.jacasi.2023.07.008 59 KongP.ChristiaP.FrangogiannisN

Imagine multiple taps pouring water into a bucket