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For instance, while cyclic peptides like CyRL-QN15 gain enzymatic resistance through rigid structures [84], tripeptides such as GHK maintain therapeutic potency while being more adaptable and versatile in formulation

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Selective Gsto2 knockdown prevents the early and late onset of motor symptoms in Trkb Penk -KO mice Penk -KO The above results suggest that disrupted TrkB signalling in iSPNs affects GSHascorbate metabolism, particularly GSTO2, which impacts the DA system and thus energy metabolism