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In one study [51], the authors observed 72 patients with VHA infection, of whom 12 had ALF and received NAC at a dose of 100 mg/kg orally every 4 h for the first 16 h, followed by the same dose at intervals of 68 h as long as required for normalization of laboratory tests

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Under those conditions the hepatoprotective effects of silymarin appear to depend mainly on five properties: activity against lipid peroxidation as a result of free radical scavenging and the ability to increase the cellular content of glutathion (GSH) [34, 51]

Further, it suggested that downregulation of HER-2/neu gene expression might be responsible for the anticancer activity of this peptide[5, 6]

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