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Glutamate production from ammonia via glutamate dehydrogenase 2 activity supports cancer cell proliferation under glutamine depletion

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Conversely, concentrations exceeding 300 M (systemic overexposure) cause AhR hyperactivation, inducing Foxp3 + Tregs via AhR-dependent Foxp3 locus acetylation and upregulating IDO1 in DCsnarrowing the therapeutic window (114, 170)

Metabolite reactions and subsystems analyses The Human Genome Scale Metabolic Model or RECON 2.2

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