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A recent consensus paper by Schuetz et al

Clinical logic, not popularity, should determine what gets added to a protocol

Rapid weight loss without proper guidance can result in significant muscle loss slowing your metabolism and increasing regain risk of weight lost is fat when GLP-1 combined with protein protocol better long-term weight maintenance with muscle preservation protocol GLP-1 and GIP medications are generally well-tolerated when properly prescribed and monitored

It has not been approved by the Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any disease

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It is possible that compensatory mechanisms could develop that reduce efficacy with prolonged use