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185,186,187 Collectively, these mechanisms reduce T-cell proliferation and cytokine secretion and increase the expression of inhibitory receptors such as PD-1 and T-cell immunoglobulin and mucin-domain containing-3 (TIM-3)

The increase in gonadotropins stimulates testicular activity, including sperm production

Tinnitus Retraining Therapy (TRT) is another notable approach in treating tinnitus