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Normally, these enzymes reduce endocytosed iron, making it suitable for further transport by DMT1 from endosomes to the cytoplasm 51

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In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states

Production of ROS is counterbalanced by ROS detoxification to regulate ROS homeostasis, including a complex antioxidant system within mitochondria

Meanwhile, insulin resistance (IR) not only co-occurs with depressive symptoms but also contributes to poor antidepressant treatment response and is closely associated with metabolic subtype depressionrepresenting a shared biological mechanism underlying both depression and T2DM (Khawagi et al., 2024

Eight different isoenzymes of GPxs exist, differing in their localization and specificity for phospholipid peroxides, cholesterol peroxides and others