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Explant of human or animal spinal segments have proven extremely valuable, because they overcome the ethical limitation of applying high energy trauma in-vivo and because the culture environment is largely controllable without losing the native tissue and organ structure

This is a direct, mechanistic relationship rooted in the Widmark model

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The Women's Health Initiative: what the trial actually tested, what the 2002 result said, and what 24 years of follow-up have shown since then