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In contrast, a meta-analysis that used less stringent selection criteria included 17 small trials and found evidence of a blood pressure-lowering effect of coenzyme Q 10 in patients with cardiovascular disease or metabolic disorders (48)

Reduced electron flow through complexes I and III slows downstream OXPHOS, leading to substrate accumulation and impaired metabolic flexibility ( AMP-activated protein kinase (AMPK) plays a critical but context-dependent role in this process (Qi and Young, 2015)

The exact molecular mechanism by which creatine exert its neuroprotective effect is not clearly understood

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In an in vivo study, after intravenous administration of modified MNTs with polyethylene glycol into mice with Cloudman S91 melanoma, it revealed improved accumulation in the tumor site [111]