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Gender is a potential confounder in studies of autistic disorder because the condition is four times more common in males than females [99]

SAEs were reported in 2 participants (1.7%)

These include regulation of mechanisms controlling reactive oxygen species (ROS), which cause macromolecular damage 16,17 , mitochondrial turnover or mitophagy 18 , and the mitochondrial unfolded protein response (UPR mt ), in which mitochondrial damage can be prevented by the removal of aggregated or unfolded proteins 19

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This increase in IL levels can lead to Diabetes and result in a refractory repair and the onset of insulin resistance in patients with DM ( Figure 3 )

Treatment is usually effective for Vitamin B12 deficiency