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An open-label, multicenter, phase I, dose escalation study with phase II expansion cohort to determine the safety, pharmacokinetics, and preliminary antitumor activity of intravenous TKM-080301 in subjects with advanced hepatocellular carcinoma

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56 However, more direct assessments of intracellular oxidant stress through measurement of GSSG formation showed no evidence of oxidant stress during the metabolism phase in rats, 64 mice, 65 or mouse hepatocytes