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Multiple tumor suppressors that repress PI3K/AKT/mTOR and HIF-1 signaling are epigenetically silenced by promoter hypermethylation, including PTEN 126, 127, 128, 129, 130 , LKB1, 131, 132 VHL 133, 134, 135, 136 and prolyl hydroxylases (PHD1/2/3)

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Alcohol increased the abundance of stearoyl-myristoyl-glycero-phosphocholine, PC-DAG, and palmitoyl-hydroxy-glycero-phosphoethanolamine, and decreased Lyso-PC (22:6), oleamide, spermine, indole-acetyl-glutamate and three predicted acyl-carnitines (Fig

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