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The BBB of mice was found to be largely intact, as confirmed by various assays for leakage of components of the periphery into the CNS, including horseradish peroxidase [39, 40], immunohistochemistry [40], and radioactive tracers [41], which is why it was long believed that the cuprizone-induced demyelination occurs without peripheral involvement

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Schrder et al

BPC-157 (Body Protection Compound): Conhecido como composto de proteo corporal, um pentadecapeptdeo gstrico estudado por sua potente ao na angiognese e no reparo de tecidos moles, como tendes e ligamentos 1

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The evidence base for TB-500 is thinner than BPC-157s, with essentially no human randomised controlled trial data (source)