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The biochemical results were nothing short of striking: after just 16 weeks of targeted supplementation, intracellular glutathione concentrations in the older cohort skyrocketed by an astonishing 164%, successfully and completely correcting the cellular deficiency to match levels typically found in healthy young adults in their twenties

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In the presence of 1 M cysteine and 10 M GSH that are approximately 1/100 of the physiological concentrations, Cys-SSSH and GSSSH were also produced to a similar level to Cys-SSH and GSSH

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In contrast, -LA improved hyperinsulinemia and the higher levels of free fatty acids of the T2DM rats [129], increases antioxidant defense through Nrf2, and reduces inflammation in T2DM (decreases TNF- and Inhibit the expression of NLRP3 and downstream inflammatory factors IL-18 and IL-1) to prevent liver steatosis and relieve HFD-induced liver lipid accumulation in T2DM rats (Table 7)