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IJMS 24 , 1962 (2023)

My wifes serum B12 levels are above average to high (737 to 1,484), yet she is B12 deficient

Individual variations in capillary fragility, skin thickness, and subcutaneous fat distribution all play roles

Shortening the time from the onset of ALS symptoms to diagnosis is essential to evaluate and initiate treatments and therapeutics sooner, especially if they exert a meaningful disease-modifying effect

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Moreover, combined administration of berberine (25 mg/kg/day) and caffeine (2.5 mg/kg/day) for four weeks prevented motor deficits, weight reduction, and DA depletion in rats exposed to rotenone compared to monotherapy of berberine or caffeine in a more recent study (132)