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Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling

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This is the reason glutathione is most often used in skin whitening treatments

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High-dose use While trials have tested up to 1200mg/day (even as high as 2400mg/day) and illustrated safety, some report higher rates of gastrointestinal side effects, dizziness, and skin reactions at these levels.14 28 38 Additionally, these higher doses are often short-term (35 weeks) and used under clinical supervision

Ill be monitoring my health over the next few weeks, but so far I feel very good following the treatment and was put at ease at every stage