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Despite targeting both isoforms of GLS1, when CB-839 was tested against a panel of breast cancer cells, its effectiveness was limited to triple-negative breast cancer cells, which have elevated GAC expression and activity compared to receptor-positive cells (Gross et al, 2014)

This initial work set the stage for subsequent studies to explore redox-sensitive targets in skeletal muscle

Antioxidants are naturally occurring substances that combat oxidative damage in biological entities

The body exhibits two forms for it: oxidized (GSSG) and reduced (GSH)

Chemotherapy drugs known to cause CIPN include platinum compounds (eg, oxaliplatin, cisplatin), taxanes (eg, paclitaxel, docetaxel), vinca alkaloids (eg, vincristine, vinorelbine), the immunomodulatory agent thalidomide (Thalidomid), and the proteasome inhibitor bortezomib (Velcade) (Loprinzi, Lacchetti 2020

M1 macrophages are involved in the immune response and immune monitoring through antigen presentation and the release of pro-inflammatory cytokines like IL-1 and TNF- (87)