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BrysonV.VogelH

277,278,279 When dysfunctional mitochondria cannot be cleared in time by mitophagy, damaged mitochondria accumulate, which results in insufficient energy supply as well as overproduced ROS, thereby triggering intense oxidative stress and cellular damage

Avoid the use of acetaminophen and codeine phosphate tablets in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine

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(4) Standard therapy combines atropine, which antagonizes muscarinic receptor overstimulation, with pralidoxime (2-PAM), which reactivates uninhibited or non-aged AChE