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This is because folate supplementation may improve symptoms to the point that the B12 deficiency is not detected in tests, and therefore is not treated

Saukkonen T, Shojaee-Moradie F, Williams RM, Amin R, Yuen KC, Watts A, Acerini CL, Umpleby AM, Dunger DB

again, this is relevant mainly for oral supplementation, but it suggests caution in patients taking separate high-dose biotin supplements

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