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Key takeaways Vitamin B12 absorption is a complex process involving multiple steps in the digestive system Taking B12 on an empty stomach can increase passive absorption by about 60%, especially beneficial for high-dose supplements Active absorption of B12 may be more efficient when taken with food , as food stimulates the release of protein to help absorb the vitamin Understanding vitamin B12 absorption The absorption of vitamin B12 is a multi-step process that involves several components of the digestive system

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