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However, UBXD8, a protein in the ER-associated degradation (ERAD) pathway, can bind PNPLA2, preventing the interaction with ABHD5, thereby segregating PNPLA2 to valosin-containing protein (VCP)/p97 segragrase that promotes extraction and subsequent Ub-dependent degradation (132) (Figure 1)

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Furthermore, the NNMT SNP rs694539 increases risk of acute lymphoblastic leukemia ( NNMT is expressed mainly in the liver and adipose tissue, and a small amount of NNMT can be detected in the kidney, lung, skeletal muscle, and the heart ( NNMT expression is altered in metabolic diseases such as obesity and cirrhosis (27), colorectal cancer (28), bladder cancer (29), ovarian cancer (30), cutaneous malignant melanoma (CMM) (31), gastric cancer (32), pancreatic cancer (33, 34), and glioblastoma (GBM) (35)

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[58] [59] Contrary to popular belief, research suggests that acute exposure to alcohol is not neurotoxic in adults and actually prevents NMDA antagonist-induced neurotoxicity

American Journal of Physiology-Endocrinology and Metabolism