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However, this remains a preclinical finding that has not been confirmed in human pharmacokinetic studies

Topical protocols deliver the peptide directly to dermal tissue at the application site, achieving high local concentrations without systemic distribution

And, the more serious side effects, such as blood clots or congestive heart failure, are likely to occur in individuals who are already treating a preexisting condition, have heart conditions, or in those who are genetically predisposed to these conditions

Other benefits may develop over time with consistent treatment

This can be a sign of subcutaneous tissue changes even if visible signs are minimal