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Why N-Acetylcysteine (NAC) Supplementation Might be a Better Option N-Acetylcysteine (NAC) is another form of cysteine that is considered less toxic, less susceptible to oxidation (and dimerization) and is more soluble in water, making it a better source of cysteine than parenteral administration of cysteine itself, according to Atkuri et al

In an elegant series of proof-of-concept experiments, the authors demonstrated that treatment with a blocking antibody against EGFR linked to GalNac (Ctx-GalNac) led to a marked reduction in EGFR levels both in cell lines and in mice 6

First, both used slow dose escalation specifically because the gastrointestinal effects are dose-related

Sustained survival benefit in recurrent medulloblastoma by a metronomic antiangiogenic regimen: A nonrandomized controlled trial

I believe there has been a flood of hype around peptides without the necessary clinical trials

doi:10.1161/CIRCRESAHA.108.175448 177