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Chrubasik, S., Pittler, M., Roufogalis, B

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Switching a solution containing 10 mM glutamate to a glutamate-free solution results in a gradual decrease in both evoked EPSCs amplitudes and miniature EPSC amplitudes, albeit to a lesser extent, over 30 min, indicating that vesicular glutamate content can be depleted by the exocytic release of pre-filled glutamate and subsequent blockade of glutamate refilling of endocytosed vesicles (Ishikawa et al., 1996

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coli with palmitoyl-CoA in vitro

Once the tumor volume reached approximately 100 mm 3 , twelve mice were assigned at random (n = 3) and received the same treatment as previously described