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Neither compound is metabolized through shared enzymatic routes

While the Phase 2 trial did not specifically stratify outcomes by baseline eGFR, GLP-1 receptor agonists as a class have demonstrated renoprotective effects in at-risk populations

Geref was later discontinued for commercial reasons

Its deficiency results in reduced NAD + synthesis and accumulation of its substrate, NAM, leading to increased NNMT activity and further decline in NAD + levels