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Glutathione is thought to influence pigmentation by: Inhibiting tyrosinase activity Shifting melanin production from eumelanin to pheomelanin Because of this, it is used for skin lightening in some settings

(Bastyr University Research Institute, Seattle, WA, USA, 2013)

The binding to TLR2 raises intracellular -synuclein levels, which in turn activates the TLR2/MyD88/NF-B signaling cascade that causes a neuroinflammatory response (Figure 3)

Vitamin C maintains glutathione in its active, reduced form, enhancing antioxidant and skin brightening effects

Another critical action of curcumin is its interference with pathogenic protein aggregation

Nitanai Y, Satow Y, Adachi H, Tsujimoto M: Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis