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5.4 Tryptophan depletion and kynurenine accumulation: an immunosuppressive axis The profound depletion of tryptophan coupled with significant accumulation of its catabolite kynurenine (Kyn) forms a potent immunosuppressive axis in the colorectal cancer tumor microenvironment, thus remodeling immune cell function and facilitates tumor immune evasion ( Figure 3 )

10.3389/fnins.2019.00085 104 DengM.ChenH.LongJ.SongJ.XieL.LiX

301 With a molecular weight of 25 kDa, PEI is considered the gold standard for gene transfection due to its high efficiency, but it induces significant cytotoxicity and lacks biodegradability

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Moya PMO, Alfaro MM, Kazemi R, Apuche-Aviles MA, Griveau S, Bedioui F, Granados SG (2017) Simultaneous electrochemical speciation of oxidized and reduced glutathione