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The deficiency in autophagy upregulates p62, that binds to Keap1, thereby inhibiting the Keap1-Cul3-E3 ubiquitin ligase complex and stabilizing Nrf2 (Lau et al., 2010)

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In the present study, a well established rat model of periodontitis was utilized, which involves a ligature around the cervix of the mandibular first molar tooth (9, 10)