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J Cell Mol Med 21(4):648657 Parker JB et al (2023) Chelating the valley of death: deferoxamines path from bench to wound clinic

228,229 The opening of these channels is controlled by the intracellular ATP/ADP ratio

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GPX1 levels are particularly responsive to fluctuations in selenium levels compared with other selenoproteins (6)

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Consistent with inhibition of CHAC1 enzyme activity, glutathione levels in gastrocnemius muscle of the KI mice were slightly increased in heterozygotes and significantly increased in homozygotes (28% in female and 38% in male) ( Fig 2G and 2H )