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Abstract The incidence and prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver disease characterized by hepatic steatosis without substantial alcohol consumption, are rapidly increasing worldwide

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Recent studies have found that GSK3 promotes the expression of apoptosis inhibitor of macrophage (AIM) in macrophages through transcriptional activity of STAT3, leading to inflammation in visceral adipose tissue during obesity [59], and regulates WAT vascularization and metabolic disorders through AMPK-mediated modulation of HIF-2 [60]