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Spirulina, often called blue-green algae, is actually a type of blue bacteria rich in nutrients

Support antioxidant defense

Iron is a necessary condition for macrophage ferroptosis, and the most important pathway for macrophage iron regulation is the hepcidin-FPN axis (Wunderer et al., 2020)

In OA, dysregulated Wnt/-catenin signaling contributes to cartilage degradation and abnormal chondrocyte hypertrophy, with elevated -catenin promoting the expression of matrix-degrading enzymes like MMPs and ADAMTS

Future efforts should focus on understanding these mechanisms, enhancing regulations, raising public awareness, and exploring alternatives to fluoride that maintain benefits without reproductive risks

Notably, the cardiorenal protective effects of SGLT2 inhibitors are dose-dependent, with long-term treatment reducing cardiovascular-renal composite endpoint event risk by approximately 30% (Maruyama-Sakurai et al., 2024)