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59% Increase in total sleep time vs placebo (controlled study) 37 mo Normal sleep maintained after the last dose (chronic insomniacs) 1977 Year DSIP was first isolated 0 Documented dependence or withdrawal in clinical studies Studies show increased delta wave sleep Research on cortisol normalization Trials in chronic pain patients Demonstrated stress-reducing effects What to expect Your DSIP timeline

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[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Abdelkader H., Fathalla Z., Moharram H., Ali T.F.S., Pierscionek B

500 solutions of Norleual, D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 , piroxicam, verapamil and 7-ethoxycoumarin (low, moderate and highly metabolized controls, respectively) were prepared in acetonitrile

10.1053/jhep.1997.v26.pm0009362347 112 TianF.DongL.ZhouY.ShaoY.LiW.ZhangH.et al (2014)

Weight regain patterns The data from similar compounds suggests that most weight lost during treatment is regained within 12 to 18 months of discontinuation