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Hi Jim Recent evidence suggests altered glutamate homeostasis in the brain of patients with MS

The study from Sekhar and colleagues presents findings suggesting that GlyNAC may provide a means to diminish cellular stress and improve strength, physical function, and cognition in aged adults

The PDB IDs were GSTs from Fasciola hepatica (2WB9), Schistosoma haematobium (1OE7), Blattella germanica (4Q5R), Drosophila melanogaster (1M0U), Nilaparvata lugens (5H5I), Bombix mori (3VPQ), and Homo sapiens (6N4E)

[DOI] [PubMed] [Google Scholar] Hayashi A, Suzuki H, Itoh K, Yamamoto M, Sugiyama Y

doi: 10.1093/carcin/bgm228

Further, Zulueta and colleagues in 2018 treated IB3-1 CF cell lines with EVs derived from human lung MSCs and observed that the administration of MSC derived EVs resulted in downregulation of the transcription and protein expression of pro-inflammatory cytokines IL-1, IL-8, and IL-6 [91]