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In addition, RSV can suppress the occurrence of ferroptosis in the myocardium by increasing SLC7A11/GSH and GPX4 [193, 195]

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The anti-proliferative activity of GSNO, combined with the overexpression of GT in tumor cells, suggests the possibility of its utility in cancer therapy

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Accessed 11/3/2020, Furman JM, Barton JJ

Specifically, dysregulated neuronal energy metabolism can trigger apoptotic cascades via mitochondrial membrane potential collapse or abnormal pyruvate dehydrogenase complex phosphorylation, while targeting monocarboxylate transporter MCT2-mediated lactate shuttling or mitochondrial calcium uniporter (MCU) activity has emerged as a promising therapeutic strategy for neurodegenerative disorders